For decades, effective cancer gene therapy has been a tantalising prospect; for a therapeutic modality potentially able to elicit highly effective and selective responses, definitive efficacy outcomes have often seemed out of reach.However, steady progress in vector development and accumulated experience from previous clinical studies has finally l
Objective: To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine (TCM) based on the regulation of gene expression.Methods: Genome-wide gene expression profiles of Michigan simply boho classroom Cancer Foundation-7 (MCF-7) cells treated with or without 4 cholic acid derivatives were detect
Bayesian techniques for engineering problems, which rely on Gaussian process (GP) regression, are known for their ability to quantify epistemic and aleatory uncertainties and for being data efficient.The mathematical elegance of applying these methods usually comes at a high computational cost when compared to deterministic and empirical Bayesian m
Autophagy-dependent survival relies on a crucial oscillatory response during cellular stress.Although oscillatory behaviour is typically associated with processes like the cell cycle or circadian rhythm, emerging experimental and theoretical evidence suggests that such periodic dynamics may explain conflicting experimental results in autophagy rese